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Neurosci Biobehav Rev. 2018 Jun;89:85-98. doi: 10.1016/j.neubiorev.2018.02.012. Epub 2018 Feb 23.

The role of the cerebellum in multiple sclerosis-150 years after Charcot.

Author information

1
Neurological Clinic and Policlinic, Department of Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland. Electronic address: Katrin.parmar@usb.ch.
2
Institute for Neuropathology, University of Göttingen Medical Center, Robert-Koch-Str. 40, D-37099 Göttingen, Germany.
3
Neuroimaging Research Unit, Institute of Experimental Neurology, Division of Neuroscience, San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Via Olgettina 60, I-20132 Milan, Italy.
4
Department of Psychology, Royal Holloway, University of London, Surrey, TW20 0EX, UK.
5
Department of Brain and Behavioral Sciences, University of Pavia, and Brain Connectivity Center-IRCCS C. Mondino, 27100 Pavia, Italy.
6
Neurological Clinic and Policlinic, Department of Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland.
7
Department of Neurology, VU University Medical Centre, De Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.
8
Department of Neurology/Neuroimmunology, Multiple Sclerosis Centre of Catalonia, Hospital Universitari Vall d'Hebron, Pg. Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
9
Novartis Pharma AG, Novartis Campus, CH-4056 Basel, Switzerland.
10
Medical Imaging Analysis Center (MIAC) AG, Mittlere Strasse 83, CH- 4056 Basel, Switzerland; Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, CH-4123 Allschwil, Switzerland.
11
Research Unit for Neuronal Plasticity & Repair, Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, A-8036 Graz, Austria.
12
Section of Neuroradiology and MRI Unit, Department of Radiology, Hospital Univeritari Vall d'Hebron, Pg. Vall d'Hebron, 119-129, 08035 Barcelona, Spain.
13
Neurological Clinic and Policlinic, Department of Medicine, University Hospital Basel, Petersgraben 4, CH-4031 Basel, Switzerland; Department of Biomedical Engineering, University of Basel, Gewerbestrasse 14, CH-4123 Allschwil, Switzerland.

Abstract

Despite its functional importance and well known clinical impact in Multiple Sclerosis (MS), the cerebellum has only received significant attention over the past few years. It is now established that the cerebellum plays a key role not only in various sensory-motor networks, but also in cognitive-behavioural processes, domains primarily affected in patients with MS. Evidence from histopathological and magnetic resonance imaging (MRI) studies on cerebellar involvement in MS is increasingly available, however linking these pathological findings with clinical dysfunction remains challenging. There are promising advances in technology that are likely to improve the detection of pathological changes within the cerebellum, which may elucidate how pathology relates to disability.

KEYWORDS:

Atrophy; Cerebellum; Cognition; Depth-sensing computer vision; Magnetic resonance imaging; Multiple sclerosis; Neurodegeneration

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