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Obesity (Silver Spring). 2018 Apr;26(4):723-729. doi: 10.1002/oby.22141. Epub 2018 Feb 24.

No Significant Effect of Maternal Perception of the Food Environment on Reproductive Success or Pup Outcomes in C57BL/6J Mice.

Gibbs VK1,2,3,4,5, Schwartz TS6,7, Johnson MS1, Patki A8, Nagy TR1,2,3,4,9, George BJ6, Allison DB1,2,3,4,6,8.

Author information

1
Department of Nutrition Sciences, University of Alabama at Birmingham, Birmingham, Alabama, USA.
2
Nutrition Obesity Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
3
Comprehensive Center for Healthy Aging, University of Alabama at Birmingham, Birmingham, Alabama, USA.
4
Nathan Shock Center of Excellence, University of Alabama at Birmingham, Birmingham, Alabama, USA.
5
Department of Biology, Birmingham-Southern College, Birmingham, Alabama, USA.
6
Office of Energetics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
7
Department of Biological Sciences, Auburn University, Auburn, Alabama, USA.
8
Department of Biostatistics, University of Alabama at Birmingham, Birmingham, Alabama, USA.
9
Diabetes Research Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.

Abstract

OBJECTIVE:

Prior work concerning maternal perception of the food environment suggests that perceived disparities in food resources resulted in reduced pup mass and dam reproductive success. This study attempted to replicate this result with increased sample size and additional measures.

METHODS:

Female C57BL/6J mice (n = 160; 3 weeks old) were randomly assigned to either subject or peer and were pair housed in partitioned cages with olfactory and visual contact. After a 6-week maturation period on an energy-rich cafeteria diet, cages were randomly assigned to Control (subject and peer fed pelleted diet) or Treatment (subject fed pellets, peer fed cafeteria diet), and subjects were bred. After weaning, one pup from each sex per litter was reared to 5 months.

RESULTS:

Treatment did not affect the number of births, pup size at birth, or the proportion of pups surviving to weaning (P > 0.09). Treatment did not affect dam body or fat mass at parturition (P > 0.22), but these measures were higher in some Treatment dams at weaning (P < 0.05). Smaller female pups were weaned from Treatment dams pregnant on the first breeding attempt (P = 0.01), but no other pup effects were observed (P > 0.07).

CONCLUSIONS:

Exposure to food-environment disparity in this study did not replicate previous findings or affect pup growth after weaning.

PMID:
29476611
PMCID:
PMC5866215
DOI:
10.1002/oby.22141
[Indexed for MEDLINE]
Free PMC Article

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