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Nat Cell Biol. 2018 Mar;20(3):233-242. doi: 10.1038/s41556-018-0037-z. Epub 2018 Feb 23.

Cargo recognition and degradation by selective autophagy.

Author information

1
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA.
2
Life Sciences Institute and Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI, USA. Klionsky@umich.edu.

Abstract

Macroautophagy, initially described as a non-selective nutrient recycling process, is essential for the removal of multiple cellular components. In the past three decades, selective autophagy has been characterized as a highly regulated and specific degradation pathway for removal of unwanted cytosolic components and damaged and/or superfluous organelles. Here, we discuss different types of selective autophagy, emphasizing the role of ligand receptors and scaffold proteins in providing cargo specificity, and highlight unanswered questions in the field.

PMID:
29476151
PMCID:
PMC6028034
DOI:
10.1038/s41556-018-0037-z
[Indexed for MEDLINE]
Free PMC Article

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