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Nanomedicine. 2018 Jun;14(4):1123-1136. doi: 10.1016/j.nano.2018.01.020. Epub 2018 Feb 21.

Neuroprotective effect of gold nanoparticles composites in Parkinson's disease model.

Author information

1
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China; Joint Laboratory of Laser Oncology with Cancer Center of Sun Yet-sen University, South China Normal University, Guangzhou, China.
2
School of Life Science, South China Normal University, Guangzhou, China.
3
MOE Key Laboratory of Laser Life Science & Institute of Laser Life Science, College of Biophotonics, South China Normal University, Guangzhou, China; Joint Laboratory of Laser Oncology with Cancer Center of Sun Yet-sen University, South China Normal University, Guangzhou, China; School of Life Science, South China Normal University, Guangzhou, China. Electronic address: guanyq@scnu.edu.cn.

Abstract

Parkinson's disease (PD) is second most common neurodegenerative disorder worldwide. Although drugs and surgery can relieve the symptoms of PD, these therapies are incapable of fundamentally treating the disease. For PD patients, over-expression of α-synuclein (SNCA) leads to the death of dopaminergic neurons. This process can be prevented by suppressing SNCA over-expression through RNA interference. Here, we successfully synthesized gold nanoparticles (GNP) composites (CTS@GNP-pDNA-NGF) via the combination of electrostatic adsorption and photochemical immobilization, which could load plasmid DNA (pDNA) and target specific cell types. GNP was transfected into cells via endocytosis to inhibiting the apoptosis of PC12 cells and dopaminergic neurons. Simultaneously, GNP composites are also used in PD models in vivo, and it can successfully cross the blood-brain barrier by contents of GNP in the mice brain. In general, all the works demonstrated that GNP composites have good therapeutic effects for PD models in vitro and in vivo.

KEYWORDS:

Gold nanoparticles; Nerve growth factor (NGF); Neuroprotective effect; Parkinson's disease; Plasmid DNA

PMID:
29474924
DOI:
10.1016/j.nano.2018.01.020

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