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Saudi J Biol Sci. 2018 Feb;25(2):213-219. doi: 10.1016/j.sjbs.2017.10.010. Epub 2017 Oct 10.

Anti-hypertensive and cardioprotective effects of a novel apitherapy formulation via upregulation of peroxisome proliferator-activated receptor-α and -γ in spontaneous hypertensive rats.

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College of Life Science, Fujian Agriculture and Forestry University, Fuzhou 350000, China.
College of Bee Science, Fujian Agriculture and Forestry University, Fuzhou 350000, China.
National United Engineering Laboratory of Natural Biological Toxins, Fuzhou 350000, China.


Ventricular remodeling is associated with many heart diseases, and ventricular remodeling induced by hypertension can be fatal independent of hypertension. In this study, we prepared a novel apitherapy formulation, designated Bao-Yuan-Ling (BYL), which contained propolis, royal jelly, and bee venom, to treat spontaneous hypertensive rats (SHRs). We then evaluated the pharmacology of BYL and the potential mechanisms through which BYL affects hypertension and ventricular remodeling. We found that BYL treatment could reduce blood pressure in SHRs. Thereafter, we found that BYL treatment reduced serum levels of angiotensin II, endothelin 1, and transforming growth factor-β and improved the myocardial structure. Moreover, the results of quantitative real-time polymerase chain reaction indicated that BYL treatment could upregulate the mRNA expression of peroxisome proliferator-activated receptor (PPAR)-α and PPAR-γ. Thus, we could conclude that BYL had hypotensive and cardioprotective effects in SHRs, potentially through improvement of myocardial energy metabolism.


Antihypertension; Apitherapy; Bee products; Cardiac protection; Peroxisome proliferator-activated receptor

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