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Curr Opin Cell Biol. 2018 Feb;50:57-63. doi: 10.1016/j.ceb.2018.01.009. Epub 2018 Feb 20.

How to build a phagosome: new concepts for an old process.

Author information

1
Inserm, U1016, Institut Cochin, Paris, France; CNRS, UMR 8104, Paris, France; Université Paris Descartes, Sorbonne Paris Cité, Paris, France. Electronic address: florence.niedergang@inserm.fr.
2
Program in Cell Biology, Hospital for Sick Children, Toronto, ON, Canada; Keenan Research Centre for Biomedical Science, St. Michael's Hospital, Toronto, ON, Canada; Department of Biochemistry, University of Toronto, Toronto, ON, Canada.

Abstract

Phagocytosis is a complex and elegant mechanism requiring finely coordinated deformation and restructuring of the membrane and the underlying cytoskeleton. Here we discuss the early events of receptor clustering and engagement required for signal transduction and actin remodeling. In addition, we summarize recent studies of the mechanisms whereby the nascent phagosome seals and evolves into a degradative phagolysosome by a process that seemingly involves the autophagic machinery. These studies provided new insights of the molecular basis of this long-appreciated, essential homeostatic process.

PMID:
29471269
DOI:
10.1016/j.ceb.2018.01.009
[Indexed for MEDLINE]

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