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J Pediatr Endocrinol Metab. 2018 Mar 28;31(3):289-295. doi: 10.1515/jpem-2017-0275.

Association of insulin-like growth factor-1 and IGF binding protein-3 with 25-hydroxy vitamin D in pre-pubertal and adolescent Indian girls.

Author information

1
Senior Consultant Endocrinology and Scientific Advisor (Projects), ILSI-India, Flat No. 17, Gautam Apartments, Gautam Nagar, New Delhi 110049, India.
2
Officer's Training College, Lucknow, India.
3
Department of Endocrinology, Sanjay Gandhi Post Graduate Institute, Lucknow, India.
4
Department of Endocrinology and Metabolism, AIIMS, New Delhi, India.
5
Department of Medicine, Sur Homeopathic College, New Delhi, India.
6
Sanjay Gandhi Post Graduate Institute, Lucknow, India.
7
Central Council of Research in Homeopathy, Ministry of Ayush, New Delhi, India.
8
BHMS, Sur Homeopathic College, New Delhi, India.
9
Department of Endocrinology and Metabolism, Medanta Hospital, Gurugram, Haryana, India.

Abstract

BACKGROUND:

There is a high prevalence of vitamin D deficiency (VDD) in India. Molecular mechanisms suggest a strong relationship between vitamin D and growth factors. However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD. The objective of the study was to assess the relationship between growth factors and serum vitamin D-parathormone (PTH) status in school girls and study the impact of vitamin D supplementation on growth factors in pre-pubertal girls with VDD.

METHODS:

Our study subjects were apparently healthy school girls aged 6-18 years. The baseline height, weight, body mass index (BMI), pubertal status, serum 25-hydroxy vitamin D (25OHD), PTH, IGF-1 and IGFBP-3 were assessed in 847 girls aged 6-18 years and in 190 pre-pubertal girls with VDD following supplementation.

RESULTS:

The mean age, BMI and serum 25OHD of girls were 11.5±3.2 years, 18.7±4.8 kg/m2 and 9.9±5.6 ng/mL, respectively. VDD was observed in 94.6% of girls. Unadjusted serum IGF-1 levels and IGF-1/IGFBP-3 molar ratio were significantly higher in girls with severe VDD as compared to girls with mild-to-moderate VDD. However, these differences disappeared when adjusted for age, height or sexual maturation. The serum IGF-1 and IGFBP-3 levels increased significantly post supplementation with vitamin D.

CONCLUSIONS:

There were no differences in serum IGF-1 levels and the IGF-1/IGFBP-3 molar ratio among VDD categories when adjusted for age, height and sexual maturation in girls. Vitamin D supplementation resulted in a significant increase in serum IGF-1 levels in VDD pre-pubertal girls.

KEYWORDS:

adolescents; insulin-like growth factor (IGF-1); insulin-like growth factor binding protein-3 (IGFBP-3); vitamin D deficiency

PMID:
29470176
DOI:
10.1515/jpem-2017-0275
[Indexed for MEDLINE]

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