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J Pediatr Endocrinol Metab. 2018 Mar 28;31(3):289-295. doi: 10.1515/jpem-2017-0275.

Association of insulin-like growth factor-1 and IGF binding protein-3 with 25-hydroxy vitamin D in pre-pubertal and adolescent Indian girls.

Author information

Senior Consultant Endocrinology and Scientific Advisor (Projects), ILSI-India, Flat No. 17, Gautam Apartments, Gautam Nagar, New Delhi 110049, India.
Officer's Training College, Lucknow, India.
Department of Endocrinology, Sanjay Gandhi Post Graduate Institute, Lucknow, India.
Department of Endocrinology and Metabolism, AIIMS, New Delhi, India.
Department of Medicine, Sur Homeopathic College, New Delhi, India.
Sanjay Gandhi Post Graduate Institute, Lucknow, India.
Central Council of Research in Homeopathy, Ministry of Ayush, New Delhi, India.
BHMS, Sur Homeopathic College, New Delhi, India.
Department of Endocrinology and Metabolism, Medanta Hospital, Gurugram, Haryana, India.



There is a high prevalence of vitamin D deficiency (VDD) in India. Molecular mechanisms suggest a strong relationship between vitamin D and growth factors. However, there is a paucity of literature with regard to a relationship between insulin-like growth factor-1 (IGF-1), insulin-like growth factor binding protein-3 (IGFBP-3) and vitamin D particularly in subjects with VDD. The objective of the study was to assess the relationship between growth factors and serum vitamin D-parathormone (PTH) status in school girls and study the impact of vitamin D supplementation on growth factors in pre-pubertal girls with VDD.


Our study subjects were apparently healthy school girls aged 6-18 years. The baseline height, weight, body mass index (BMI), pubertal status, serum 25-hydroxy vitamin D (25OHD), PTH, IGF-1 and IGFBP-3 were assessed in 847 girls aged 6-18 years and in 190 pre-pubertal girls with VDD following supplementation.


The mean age, BMI and serum 25OHD of girls were 11.5±3.2 years, 18.7±4.8 kg/m2 and 9.9±5.6 ng/mL, respectively. VDD was observed in 94.6% of girls. Unadjusted serum IGF-1 levels and IGF-1/IGFBP-3 molar ratio were significantly higher in girls with severe VDD as compared to girls with mild-to-moderate VDD. However, these differences disappeared when adjusted for age, height or sexual maturation. The serum IGF-1 and IGFBP-3 levels increased significantly post supplementation with vitamin D.


There were no differences in serum IGF-1 levels and the IGF-1/IGFBP-3 molar ratio among VDD categories when adjusted for age, height and sexual maturation in girls. Vitamin D supplementation resulted in a significant increase in serum IGF-1 levels in VDD pre-pubertal girls.


adolescents; insulin-like growth factor (IGF-1); insulin-like growth factor binding protein-3 (IGFBP-3); vitamin D deficiency

[Indexed for MEDLINE]

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