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J Med Food. 2018 Mar;21(3):244-253. doi: 10.1089/jmf.2017.3939. Epub 2018 Feb 22.

The Effect of Aronia Berry on Type 1 Diabetes In Vivo and In Vitro.

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1 Department of Oriental Medicine Resources, Chonbuk National University , Iksan, South Korea .
2 Department of Oriental Pharmacy, College of Pharmacy, Wongkwang-Oriental Medicine Research Institute, Wongkwang University , Iksan, South Korea .
3 Sunchang Research Institute of Health and Longevity , Sunchang, South Korea .
4 Department of Hotel and Restaurant Culinary Art, Kunjang University , Gunsan, South Korea .


The number of diabetic patients worldwide is increasing, and complications such as stroke and cardiovascular disease are becoming a serious cause of death. Diabetes mellitus is classified into two types according to the etiopathogenic mechanism and insulin dependence. Type 1 diabetes (T1D), an insulin-dependent diabetes mellitus, is caused by damage and destruction of pancreatic β cells that produce insulin. It is a disease that is characterized by hyperglycemia and hypoinsulinemia. Aronia berry has been used as a medicinal food in Europe. Aronia contains a variety of ingredients such as polyphenols, anthocyanins, flavonoids, and tannins. Especially, anthocyanin content in aronia berry is known to be much higher than in other plants and berries. It is known for exerting antioxidant, anti-inflammation, and anti-aging effects. Therefore, this study was conducted to investigate the effects of aronia berry extract intake in multiple low-dose streptozotocin (STZ)-induced T1D and to confirm the functional properties of aronia berry. ICR mice (6-week male) were divided into four groups: control (normal control group), STZ (100 mg/kg of STZ-induced T1D group), AR 10 (STZ with oral administration of aronia 10 mg/kg), and AR 100 (STZ with oral administration of aronia 100 mg/kg). Afterward, STZ was injected in a single dose to induce T1D, and the extract was orally administered daily. Dietary intake and body weight were measured twice a week. We confirmed that aronia berry has the effect of decreasing the increase of blood glucose level and also has the protection effect of pancreas β cell (RINm5F cell). This study confirms the anti-diabetic activity of aronia berry, and it can be expected to increase the utilization according to the results.


RINm5F; aronia berry; diabetes; streptozotocin

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