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Ann Hepatol. 2018 Mar 1;17(2):250-255. doi: 10.5604/01.3001.0010.8644.

More Evidence for the Genetic Susceptibility of Mexican Population to Nonalcoholic Fatty Liver Disease through PNPLA3.

Author information

1
Liver Research Unit, Medica Sur Clinic & Foundation, Mexico City.
2
Unit of Genomic, National Institute of Genomic, Mexico City, Mexico.
3
Department of Postgraduate Courses and Research, Laboratory of Molecular Biology, Superior School of Medicine, National Polytechnic Institute. Mexico City, Mexico.
4
Public Health Department, Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
5
Department of Immunology, National Institute of Cardiology "Ignacio Chávez", Mexico City, Mexico.

Abstract

BACKGROUND:

The gene for patatin-like phospholipase domain containing 3 (PNPLA3) is associated with nonalcoholic fatty liver disease (NAFLD) development. We previously found that Mexican indigenous population had the highest frequency reported of the PNPLA3 148M risk allele. Further, we observed a relationship between M148M genotype with elevated ALT levels in individuals with normal weight, overweight and obese. We sought to investigate whether PNPLA3 polymorphism is associated with NAFLD development in Mexicans.

MATERIAL AND METHODS:

We enrolled 189 Mexican patients with NAFLD and 201 healthy controls. Anthropometric, metabolic, and biochemical variables were measured, and rs738409 (Ile148Met substitution) polymorphism was genotyped by sequencing.

RESULTS:

Logistic regression analysis, using a recessive model, suggested that PNPLA3 polymorphism in Mexican population is significantly associated (OR = 1.711, 95% CI: 1.014-2.886; P = 0.044) with NAFLD.

CONCLUSIONS:

The PNPLA3 gene is associated with NAFLD in Mexican population. More studies are required to explain the high prevalence of PNPLA3 polymorphism in Mexican-Americans, Mexican-Indians, and Mexican-Mestizos.

KEYWORDS:

Nonalcoholic fatty liver disease. Patatin domain. Rs738409. Epigenetics.

PMID:
29469042
DOI:
10.5604/01.3001.0010.8644
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