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Nutrition. 2018 Apr;48:18-23. doi: 10.1016/j.nut.2017.11.022. Epub 2017 Dec 8.

Do celiac disease and non-celiac gluten sensitivity have the same effects on reproductive disorders?

Author information

1
Department of Food Science and Dietetics, Wroclaw Medical University, Wrocław, Poland. Electronic address: Joanna.pieczynska@umed.wroc.pl.

Abstract

OBJECTIVES:

The wide spectrum of clinical symptoms of celiac disease (CD) is partly due to the malnourished state caused by the malabsorption of micro- and macronutrients. It has been suggested that fertility problems and obstetric complications may be a consequence of the endocrine disorders caused by selective nutrient deficiencies. The same selective nutrient deficiencies as in CD could be a reason for fertility problems in non-celiac gluten sensitivity (NCGS). The aim of this study was to investigate the effect of nutrient deficiencies in CD and NCGS on fertility problems.

METHOD:

A literature review of fertility problems in men and women and nutrient deficiencies associated with CD and NCGS, was performed up to May 2017.

RESULTS:

The same selective nutrient deficiencies (folate, iron, vitamin B12, and vitamin D) in CD and NCGS could be a reason for fertility problems.

CONCLUSIONS:

CD is postulated to be considered in the preconceptional screening of patients with reproductive disorders, but for non-celiac gluten sensitivity, the effect on fertility is not yet proven.

KEYWORDS:

Celiac disease; Extraintestinal symptoms; Fertility; Non-celiac gluten sensitivity; Nutrient deficiencies

PMID:
29469015
DOI:
10.1016/j.nut.2017.11.022
[Indexed for MEDLINE]

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