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Curr Drug Metab. 2018;19(4):351-369. doi: 10.2174/1389200219666180220095236.

Plant-Derived Polyphenols in Human Health: Biological Activity, Metabolites and Putative Molecular Targets.

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Instituto de Biología Molecular y Celular (IBMC), Universidad Miguel Hernández (UMH), Alicante, Spain.
Department of Analytical Chemistry, University of Granada, Granada, Spain.
Research and Development of Functional Food Centre (CIDAF), PTS Granada, Granada, Spain.
Unitat de Recerca Biomedica, Hospital Universitari Sant Joan, Institut d`Investigacio Sanitaria Pere Virgili, Universitat Rovira i Virgili, Reus, Spain.
CIBER: CB12/03/30038, Fisiopatología de la Obesidad y la Nutricion, CIBERobn, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.



Hibiscus sabdariffa, Lippia citriodora, Rosmarinus officinalis and Olea europaea, are rich in bioactive compounds that represent most of the phenolic compounds' families and have exhibited potential benefits in human health. These plants have been used in folk medicine for their potential therapeutic properties in human chronic diseases. Recent evidence leads to postulate that polyphenols may account for such effects. Nevertheless, the compounds or metabolites that are responsible for reaching the molecular targets are unknown.


data based on studies directly using complex extracts on cellular models, without considering metabolic aspects, have limited applicability. In contrast, studies exploring the absorption process, metabolites in the blood circulation and tissues have become essential to identify the intracellular final effectors that are responsible for extracts bioactivity. Once the cellular metabolites are identified using high-resolution mass spectrometry, docking techniques suppose a unique tool for virtually screening a large number of compounds on selected targets in order to elucidate their potential mechanisms.


we provide an updated overview of the in vitro and in vivo studies on the toxicity, absorption, permeability, pharmacokinetics and cellular metabolism of bioactive compounds derived from the abovementioned plants to identify the potential compounds that are responsible for the observed health effects.


we propose the use of targeted metabolomics followed by in silico studies to virtually screen identified metabolites on selected protein targets, in combination with the use of the candidate metabolites in cellular models, as the methods of choice for elucidating the molecular mechanisms of these compounds.


Hibiscus sabdariffa; Lippia citriodora; Olea europaea; Polyphenols; Rosmarinus officinalis; metabolites; molecular docking.

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