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J Int Med Res. 2018 Apr;46(4):1414-1427. doi: 10.1177/0300060517752733. Epub 2018 Feb 22.

Quantification of 10 steroid hormones in human saliva from Chinese adult volunteers.

Liu J1,2, Qiu X2,3, Wang D1,2, Li Y1,4, Zong Y2, Liu Y5, Zhang Y2,3, Yang P2,3, Zuo Y2,3, Yang H2,6, Wang J2,6, Du Y4, Zi J2,3.

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1 213636 BGI Education Center, University of Chinese Academy of Sciences, Shenzhen 518083, China.
2 213636 BGI -Shenzhen, Shenzhen 518083, China.
3 China National GeneBank, 213636 BGI -Shenzhen, Shenzhen 518120, China.
4 Sports Genomics Institute, 213636 BGI -Shenzhen, Shenzhen 518083, China.
5 Institute of Advanced Technology, University of Science and Technology of China, Hefei, China.
6 James D. Watson Institute of Genome Sciences, Hangzhou 310058, China.


Objective This study was performed to investigate the effects of age and sex on 10 salivary steroid hormones and analyze the correlations between salivary and plasma hormones. Methods The concentrations of 10 salivary steroid hormones in 1090 Chinese adult volunteers were examined using liquid chromatography-tandem mass spectrometry, and a related investigation was performed on the concentrations of salivary hormones in this population. Results The concentrations of androstenedione (A4), 17α-hydroxyprogesterone (17-OHP), aldosterone (ALD), cortisone (COR), corticosterone (CORT), cortisol (F), progesterone (P), and testosterone were significantly different between men and women (Student's t-test). Differences in 17-OHP and ALD concentrations were highly significant between women in the follicular and luteal phases of their menstrual cycle (Student's t-test). Five salivary steroid hormones (17-OHP, A4, CORT, COR, and F) significantly decreased with increasing age (Kruskal-Wallis test). A high linear correlation between salivary and plasma 17-OHP, P, A4, and F were observed with obvious sex-related differences (Pearson's correlation, r > 0.7). Conclusions Our results provide important knowledge regarding the descriptive characteristics of salivary hormones in relation to age and sex and their correlations with plasma hormones.


Chinese; LC-MS/MS; Saliva; age; plasma; sex; steroid hormones

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