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Oncotarget. 2017 Dec 14;9(6):7204-7218. doi: 10.18632/oncotarget.23208. eCollection 2018 Jan 23.

Inflammatory responses and inflammation-associated diseases in organs.

Chen L#1, Deng H#1, Cui H1,2, Fang J1,2, Zuo Z1,2, Deng J1,2, Li Y1,2, Wang X1,2, Zhao L1,2.

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1
College of Veterinary Medicine, Sichuan Agricultural University, Wenjiang, Chengdu 611130, China.
2
Key Laboratory of Animal Diseases and Environmental Hazards of Sichuan Province, Sichuan Agriculture University, Wenjiang, Chengdu 611130, China.
#
Contributed equally

Abstract

Inflammation is a biological response of the immune system that can be triggered by a variety of factors, including pathogens, damaged cells and toxic compounds. These factors may induce acute and/or chronic inflammatory responses in the heart, pancreas, liver, kidney, lung, brain, intestinal tract and reproductive system, potentially leading to tissue damage or disease. Both infectious and non-infectious agents and cell damage activate inflammatory cells and trigger inflammatory signaling pathways, most commonly the NF-κB, MAPK, and JAK-STAT pathways. Here, we review inflammatory responses within organs, focusing on the etiology of inflammation, inflammatory response mechanisms, resolution of inflammation, and organ-specific inflammatory responses.

KEYWORDS:

chemokines; cytokines; inflammation; inflammatory signaling pathways; organ diseases

Conflict of interest statement

CONFLICTS OF INTEREST There are no conflicts of interest.

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