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Nat Rev Neurosci. 2018 Apr;19(4):185-196. doi: 10.1038/nrn.2018.8. Epub 2018 Feb 22.

Signalling from the periphery to the brain that regulates energy homeostasis.

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Department of Surgery, University of Michigan Health System, Ann Arbor, MI, USA.


The CNS regulates body weight; however, we still lack a clear understanding of what drives decisions about when, how much and what to eat. A vast array of peripheral signals provides information to the CNS regarding fluctuations in energy status. The CNS then integrates this information to influence acute feeding behaviour and long-term energy homeostasis. Previous paradigms have delegated the control of long-term energy homeostasis to the hypothalamus and short-term changes in feeding behaviour to the hindbrain. However, recent studies have identified target hindbrain neurocircuitry that integrates the orchestration of individual bouts of ingestion with the long-term regulation of energy balance.

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