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Mol Biol Cell. 2018 Apr 15;29(8):886-896. doi: 10.1091/mbc.E17-12-0729. Epub 2018 Mar 29.

The IDA3 adapter, required for intraflagellar transport of I1 dynein, is regulated by ciliary length.

Author information

1
Department of Cell Biology, Emory University, Atlanta, GA 30322.
2
Department of Cellular Biology, University of Georgia, Athens, GA 30602.
3
Departments of Cell Biology and Biophysics, University of Texas Southwestern Medical Center, Dallas, TX 75390.
4
Department of Genetics, Washington University School of Medicine, St. Louis, MO 63110.
5
Department of Biology, Oglethorpe University, Atlanta, GA 30319.
6
Department of Biological Sciences, Osaka University, Osaka 560-0043, Japan.
7
Department of Biological Sciences, Chuo University, Tokyo 112-8551, Japan.
8
Department of Biochemistry, University of Mississippi Medical Center, Jackson, MS 39216.

Abstract

We determined how the ciliary motor I1 dynein is transported. A specialized adapter, IDA3, facilitates I1 dynein attachment to the ciliary transporter called intraflagellar transport (IFT). Loading of IDA3 and I1 dynein on IFT is regulated by ciliary length.

PMID:
29467251
PMCID:
PMC5896928
DOI:
10.1091/mbc.E17-12-0729
[Indexed for MEDLINE]
Free PMC Article

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