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PLoS One. 2018 Feb 21;13(2):e0193299. doi: 10.1371/journal.pone.0193299. eCollection 2018.

Reduced NK cell IFN-γ secretion and psychological stress are independently associated with herpes zoster.

Author information

1
Department of Internal Medicine, Division of Infectious Diseases, Veterans Health Service Medical Center, Seoul, Korea.
2
Department of Laboratory Medicine, Veterans Health Service Medical Center, Seoul, Korea.
3
Department of Dermatology, Veterans Health Service Medical Center, Seoul, Korea.
4
Department of Psychiatry, Veterans Health Service Medical Center, Seoul, Korea.
5
Department of Microbiology and Immunology, Seoul National University College of Medicine, and Institute of Endemic Diseases, Seoul National University Medical Research Center, Seoul, Korea.

Abstract

The pathogenesis of herpes zoster is closely linked to reduced varicella-zoster virus-specific cell-mediated immunity. However, little is known about the interplay between natural killer cells and psychological stress in the pathogenesis of herpes zoster. This study aimed to investigate possible associations among natural killer cells, T cells and psychological stress in herpes zoster. Interferon-gamma secretion from natural killer cell, psychological stress events, stress cognition scale scores and cytomegalovirus-specific cell-mediated immunity were compared between 44 patients with herpes zoster and 44 age- and gender-matched control subjects. A significantly lower median level of interferon-gamma secreted by natural killer cells was observed in patients with a recent diagnosis of herpes zoster than in control subjects (582.7 pg/ml vs. 1783 pg/ml; P = 0.004), whereas cytomegalovirus-specific cell-mediated immunity was not associated with herpes zoster. Psychological stress events and high stress cognition scale scores were significantly associated in patients with herpes zoster (P<0.001 and P = 0.037, respectively). However, reduced interferon-gamma secretion from natural killer cell and psychological stress were not associated. In conclusion, patients with a recent diagnosis of herpes zoster display reduced interferon-gamma secretion from natural killer cells and frequent previous psychological stress events compared with controls. However, reduced natural killer cell activity is not an immunological mediator between psychological stress and herpes zoster.

PMID:
29466462
PMCID:
PMC5821387
DOI:
10.1371/journal.pone.0193299
[Indexed for MEDLINE]
Free PMC Article

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