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Microbiology. 2018 Apr;164(4):437-439. doi: 10.1099/mic.0.000601. Epub 2018 Feb 21.

Microbe Profile: Mycobacterium tuberculosis: Humanity's deadly microbial foe.

Author information

1
1​UCD College of Health and Agricultural Sciences, University College Dublin, Ireland.
2
2​UCD School of Veterinary Medicine, University College Dublin, Dublin, Ireland.
3
3​Infectious Disease Research Institute, 1616 Eastlake Avenue E, Suite 400, Seattle, WA 98102, USA.

Abstract

Mycobacterium tuberculosis is an expert and deadly pathogen, causing the disease tuberculosis (TB) in humans. It has several notable features: the ability to enter non-replicating states for long periods and cause latent infection; metabolic remodelling during chronic infection; a thick, waxy cell wall; slow growth rate in culture; and intrinsic drug resistance and antibiotic tolerance. As a pathogen, M. tuberculosis has a complex relationship with its host, is able to replicate inside macrophages, and expresses diverse immunomodulatory molecules. M. tuberculosis currently causes over 1.8 million deaths a year, making it the world's most deadly human pathogen.

PMID:
29465344
DOI:
10.1099/mic.0.000601
[Indexed for MEDLINE]

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