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Obesity (Silver Spring). 2018 Mar;26(3):570-577. doi: 10.1002/oby.22120.

CD Obesity-Prone Rats, but not Obesity-Resistant Rats, Robustly Ferment Resistant Starch Without Increased Weight or Fat Accretion.

Author information

1
School of Nutrition and Food Sciences, Louisiana State University Agricultural Center, Louisiana State University, Baton Rouge, Louisiana, USA.
2
Department of Entomology, Louisiana State University Agricultural Center, Louisiana State University, Baton Rouge, Louisiana, USA.
3
Department of Experimental Statistics, Louisiana State University, Baton Rouge, Louisiana, USA.
4
Department of Pathobiological Sciences, School of Veterinary Medicine, Louisiana State University, Baton Rouge, Louisiana, USA.
5
Division of Pulmonary and Critical Care Medicine, Louisiana State University Health Sciences Center, Louisiana State University, New Orleans, Louisiana, USA.
6
Department of Microbiology, Immunology and Parasitology, Louisiana State University Health Sciences Center, Louisiana State University, New Orleans, Louisiana, USA.
7
Department of Food Science, University of California, Davis, Davis, California, USA.

Abstract

OBJECTIVE:

This study used CD obesity-prone (OP) and obesity-resistant (OR) rats to examine how weight gain and fat accretion relate to fermentation levels and microbiota composition after feeding resistant starch (RS).

METHODS:

After feeding OP rats and OR rats a high-fat (HF) diet for 4 weeks, rats were stratified into three groups: they were fed either an HF diet (group 1: HF-HF) or were switched to a low-fat (LF) diet (group 2: HF-LF) or an LF diet supplemented with 20% RS by weight for 4 weeks (group 3: HF-LFRS). Energy intake, body weight, fermentation variables, and microbiota composition were determined.

RESULTS:

In OP rats, RS elicited robust fermentation (increased cecal contents, short-chain fatty acids, and serum glucagon-like peptide 1). Total bacteria, species of the Bacteroidales family S24-7, and the archaean Methanobrevibacter smithii increased. The robust fermentation did not elicit higher weight or fat accretion when compared with that of control rats fed the same isocaloric diets (HF-LF ± RS). In OR rats, body weight and fat accretion were also not different between HF-LF ± RS diets, but RS elicited minimal changes in fermentation and microbiota composition.

CONCLUSIONS:

Robust fermentation did not contribute to greater weight. Fermentation levels and changes in microbiota composition in response to dietary RS differed by obesity phenotype.

PMID:
29464911
PMCID:
PMC5826621
[Available on 2019-03-01]
DOI:
10.1002/oby.22120
[Indexed for MEDLINE]

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