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Mar Drugs. 2018 Feb 19;16(2). pii: E64. doi: 10.3390/md16020064.

The Anti-Cancer Effects of Frondoside A.

Author information

1
Department of Physiology, Faculty of Medicine and Health Sciences, United Arab Emirates University, P.O. Box 17666, Al Ain, United Arab Emirates. tadrian@uaeu.ac.ae.
2
Coastside Bio Resources, Deer Isle, ME 04627, USA. pcollin48@gmail.com.

Abstract

Frondoside A is a triterpenoid glycoside from the Atlantic Sea Cucumber, Cucumariafrondosa. Frondoside A has a broad spectrum of anti-cancer effects, including induction of cellular apoptosis, inhibition of cancer cell growth, migration, invasion, formation of metastases, and angiogenesis. In cell lines and animal models studied to date, the anti-cancer effects of the compound are seen in all solid cancers, lymphomas, and leukemias studied to date. These effects appear to be due to potent inhibition of p21-activated kinase 1 (PAK1), which is up-regulated in many cancers. In mouse models, frondoside A has synergistic effects with conventional chemotherapeutic agents, such as gemcitabine, paclitaxel, and cisplatin. Frondoside A administration is well-tolerated. No side effects have been reported and the compound has no significant effects on body weight, blood cells, or on hepatic and renal function tests after long-term administration. Frondoside A may be valuable in the treatment of malignancies, either as a single agent or in combination with other therapeutic modalities.

KEYWORDS:

angiogenesis; apoptosis; cancer; frondoside A; invasion; metastases; tumor growth

PMID:
29463049
PMCID:
PMC5852492
DOI:
10.3390/md16020064
[Indexed for MEDLINE]
Free PMC Article

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