Workflow of this in silico trial (from left to right): The process begins with a prostate patient dataset. Each dataset is entered into the planning stage, where a plan is created for all possible treatment modalities. Subsequently, each plan is evaluated by dose metrics and radiobiological models. Next, each plan is entered into the simulated delivery stage, where known likely clinical errors (target motion) along with correction strategies are introduced/simulated into the plan/delivery. Subsequently, each plan is evaluated in terms of robustness and stability, which in turn produces a score and finally a rank. This enables two conclusions to be made for these clinical conditions, planning criteria, and simulations parameters: (1) which modality is ranked highest across the cohort, and (2) which modality is ranked highest for each individual patient.