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J Gastroenterol. 2018 Apr;53(4):475-483. doi: 10.1007/s00535-018-1440-8. Epub 2018 Feb 19.

Clinical and pathophysiological aspects of type 1 autoimmune pancreatitis.

Author information

1
Department of Gastroenterology and Hepatology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan. uchidak@hirakata.knu.ac.jp.
2
Department of Gastroenterology and Hepatology, Kansai Medical University, 2-5-1 Shinmachi, Hirakata, Osaka, 573-1010, Japan.

Abstract

In 1995, Yoshida and colleagues proposed the concept of "autoimmune pancreatitis" (AIP), which has recently been recognized as a new pancreatic inflammatory disease. Recent studies have suggested the existence of two subtypes of AIP: type 1, which involves immunoglobulin G4 (IgG4) and is the pancreatic manifestation of IgG4-related disease (IgG4-RD); and type 2, which is characterized by granulocytic epithelial lesions. Type 2 AIP is thought to be rare in Japan. Type 1 AIP is characterized by increased serum IgG4 concentrations, lymphoplasmacytic infiltrations, storiform fibrosis, and obliterative phlebitis. However, although type 1 AIP has become increasingly recognized, many clinical and basic issues remain to be solved. This review provides an overview of the recent clinical and basic knowledge of type 1 AIP.

KEYWORDS:

Autoimmune pancreatitis; Basophil; IgG4; M2 macrophage; Regulatory B-cells; Regulatory T-cells

PMID:
29460239
PMCID:
PMC5866825
DOI:
10.1007/s00535-018-1440-8
[Indexed for MEDLINE]
Free PMC Article

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