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Eur Radiol. 2018 Aug;28(8):3347-3354. doi: 10.1007/s00330-017-5269-y. Epub 2018 Feb 19.

Progressive supranuclear palsy and idiopathic Parkinson's disease are associated with local reduction of in vivo brain viscoelasticity.

Author information

1
Department of Neurology, Charité - University Medicine Berlin, Augustenburger Platz 1, 13353, Berlin, Germany.
2
Department of Radiology, Charité - University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
3
Institute of Medical Informatics, Charité - University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany.
4
Department of Radiology, Charité - University Medicine Berlin, Charitéplatz 1, 10117, Berlin, Germany. ingolf.sack@charite.de.

Abstract

OBJECTIVES:

To apply three-dimensional multifrequency MR-elastography (3DMRE) for the measurement of local cerebral viscoelasticity changes in patients with Parkinson's disease (PD) and progressive supranuclear palsy (PSP).

METHODS:

T1-weighted anatomical imaging and 3DMRE were performed in 17 PD and 20 PSP patients as well as 12 controls. Two independent viscoelasticity parameters, |G*| and φ, were reconstructed combining seven harmonic vibration frequencies (30-60 Hz). Spatially averaged values were compared by one-way ANOVA, groups were compared using unpaired t test and Mann-Whitney test, respectively. Correlation between clinical data and parameters of brain elasticity and volume were calculated by Pearson's correlation coefficient.

RESULTS:

In patients, |G*| was significantly reduced in the frontal and mesencephalic regions (p < 0.05). Beyond that, reduced mesencephalic |G*| discriminated PSP from PD (p < 0.05). Neurodegeneration causes significant brain atrophy (p < 0.01) and is pronounced in PSP patients (p < 0.05 vs. PD). Reduced brain viscoelasticity is correlated with brain atrophy in PSP (r=0.64, p=0.002) and PD (r=0.65, p=0.005) patients but not in controls.

CONCLUSIONS:

MRE-measured viscoelasticity reflects local structural changes of brain tissue in PSP and in PD and provides a useful parameter to differentiate neurodegenerative movement disorders based on imaging examinations.

KEY POINTS:

• 3D multifrequency MR-elastography reveals diffuse regional changes in brain viscoelasticity in neurodegenerative disorders. • Reduced mesencephalic viscoelasticity separates PD and PSP. • Reduced brain viscoelasticity and brain atrophy as independent hallmarks of neurodegeneration hypothesized.

KEYWORDS:

Magnetic resonance elastography, MRE; Mesencephalon; Parkinson’s disease; Progressive supranuclear palsy; Tau protein

PMID:
29460073
DOI:
10.1007/s00330-017-5269-y
[Indexed for MEDLINE]

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