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Trends Cancer. 2018 Feb;4(2):93-94. doi: 10.1016/j.trecan.2017.11.008. Epub 2017 Dec 9.

The Sympathetic Nervous System Drives Tumor Angiogenesis.

Author information

1
School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, Faculty of Health and Medicine, University of Newcastle, Callaghan NSW 2308, Australia. Electronic address: hubert.hondermarck@newcastle.edu.au.
2
School of Biomedical Sciences and Pharmacy, Hunter Medical Research Institute, Faculty of Health and Medicine, University of Newcastle, Callaghan NSW 2308, Australia.

Abstract

Neurobiology is increasingly contributing to cancer research. Recent work indicates that noradrenaline released by sympathetic adrenergic nerves in prostate cancer can stimulate β-adrenoceptors in endothelial cells. This leads to the alteration of endothelial cell metabolism toward the inhibition of oxidative phosphorylation and the induction of an angiogenic switch that fuels cancer progression. These findings suggest that the sympathetic nervous system is a higher-level control of tumor angiogenesis that could be targeted in clinical oncology.

KEYWORDS:

adrenergic signaling; angiogenesis; autonomic nervous system; cancer; metabolism; sympathetic nerves

PMID:
29458965
DOI:
10.1016/j.trecan.2017.11.008
[Indexed for MEDLINE]

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