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AIDS Behav. 2018 Jul;22(Suppl 1):99-104. doi: 10.1007/s10461-018-2053-1.

Mortality Rate and Predictors in Children Under 15 Years Old Who Acquired HIV from Mother to Child Transmission in Paraguay.

Author information

1
Research Directorate General, National University of Caaguazú, Km 138 Ruta N°8 Blas A. Garay, 8, Coronel Oviedo, Paraguay. gloria.aguilar@unca.edu.py.
2
Department of Strategic Information and Surveillance, National HIV Program, Asunción, Paraguay. gloria.aguilar@unca.edu.py.
3
Post Graduation Program in Infectious Diseases, Federal University of Espirito Santo, Vitoria, Brazil. gloria.aguilar@unca.edu.py.
4
Post Graduation Program in Infectious Diseases, Federal University of Espirito Santo, Vitoria, Brazil.
5
Global Health Sciences, University of California, San Francisco, CA, USA.
6
Department of Public Health, University of the Frontier, Temuco, Chile.
7
Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, CA, USA.
8
Department of Strategic Information and Surveillance, National HIV Program, Asunción, Paraguay.
9
Department of Pediatrics, Institute of Tropical Medicine, Asunción, Paraguay.
10
Faculty of Medical Sciences, National University of Caaguazú, Coronel Oviedo, Paraguay.

Abstract

We estimated mortality rate and predictors of death in children and adolescents who acquired HIV through mother-to-child transmission in Paraguay. In 2000-2014, we conducted a cohort study among children and adolescents aged < 15 years. We abstracted data from medical records and death certificates. We used the Cox proportional hazards model for the multivariable analysis of mortality predictors. A total of 302 subjects were included in the survey; 216 (71.5%) were younger than 5 years, 148 (51.0%) were male, and 214 (70.9%) resided in the Asunción metropolitan area. There were 52 (17.2%) deaths, resulting in an overall mortality rate of 2.06 deaths per 100 person-years. The children and adolescents with hemoglobin levels ≤ 9 g/dL at baseline had a 2-times higher hazard of death compared with those who had levels > 9 g/dL (HR 2.27, 95% CI 1.01-5.10). The mortality of HIV-infected children and adolescents in Paraguay is high, and anemia is associated with mortality. Improving prenatal screening to find cases earlier and improving pediatric follow-up are needed.

KEYWORDS:

Child; HIV; Mortality; Paraguay

PMID:
29455264
PMCID:
PMC6126538
DOI:
10.1007/s10461-018-2053-1
[Indexed for MEDLINE]
Free PMC Article

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