Format

Send to

Choose Destination
Curr Opin Neurobiol. 2018 Apr;49:108-115. doi: 10.1016/j.conb.2018.01.008. Epub 2018 Feb 20.

Mixed selectivity encoding and action selection in the prefrontal cortex during threat assessment.

Author information

1
Biology Department, Hunter College, CUNY, United States; Neuroscience Collaborative, The Graduate Center, CUNY, United States.
2
Biology Department, Hunter College, CUNY, United States; Neuroscience Collaborative, The Graduate Center, CUNY, United States. Electronic address: elikhtik@genectr.hunter.cuny.edu.

Abstract

The medial prefrontal cortex (mPFC) regulates expression of emotional behavior. The mPFC combines multivariate information from its inputs, and depending on the imminence of threat, activates downstream networks that either increase or decrease the expression of anxiety-related motor behavior and autonomic activation. Here, we selectively highlight how subcortical input to the mPFC from two example structures, the amygdala and ventral hippocampus, help shape mixed selectivity encoding and action selection during emotional processing. We outline a model where prefrontal subregions modulate behavior along orthogonal motor dimensions, and exhibit connectivity that selects for expression of one behavioral strategy while inhibiting the other.

PMID:
29454957
PMCID:
PMC5889962
[Available on 2019-04-01]
DOI:
10.1016/j.conb.2018.01.008

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center