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Clin Neurol Neurosurg. 2018 Apr;167:65-69. doi: 10.1016/j.clineuro.2018.02.017. Epub 2018 Feb 12.

The positive effect of venlafaxine on central motor conduction.

Author information

1
Dept. Cerebral Vascular Disease, The General Hospital of Guangzhou Military Command of PLA, No. 111, Liuhua Avenue, Yuexiu District, Guangzhou, 510010, PR China. Electronic address: xuehonglcy@163.com.
2
Area 2, Department of Neurology, Jiangmen Central Hospital, No.23, Haibang Street, Beijie, Jiangmen City, Guangdong Province, PR China. Electronic address: liufuda2008@163.com.
3
Dept. Neurology, The General Hospital of Guangzhou Military Command of PLA, No.111, Liuhua Avenue, Yuexiu District, Guangzhou, 510010, PR China. Electronic address: hypeng2000@sina.com.
4
Dept. Neurology, The General Hospital of Guangzhou Military Command of PLA, No.111, Liuhua Avenue, Yuexiu District, Guangzhou, 510010, PR China. Electronic address: annajing@hotmail.com.
5
Dept. of Neurology, Shunde Guizhou Hospital, Fushan, Guangdong, PR China. Electronic address: songxuezhu109@126.com.
6
Dept. of Rehabilitation Medicine, The General Hospital of Guangzhou Military Command of PLA, No.111, Liuhua Avenue, Yuexiu, Guangzhou, 510010, PR China. Electronic address: xhuaqi@163.com.
7
Dept. of Neurology, The Second People's Hospital of Zhuhai, No. 208, Yuehua Avenue, Zhuhai, Guangdong Province, 510260, PR China. Electronic address: liyingkaizhh@163.com.
8
Dept. Cerebral Vascular Disease, The General Hospital of Guangzhou Military Command of PLA, No. 111, Liuhua Avenue, Yuexiu District, Guangzhou, 510010, PR China. Electronic address: 13060812626@163.com.

Abstract

OBJECTIVES:

Using the triple stimulation technique (TST) and conventional transcranial magnetic stimulation (TMS), this study was designed to investigate the effect of venlafaxine on central motor conduction in healthy adults.

PATIENTS AND METHODS:

In this crossover, self-controlled trial, eight healthy adult volunteers were randomly divided into groups A and B. In group A, the volunteers were administered 1 venlafaxine capsule once daily for 7 consecutive days, followed by a 3-day break. Next, volunteers in this group received 1 placebo capsule once daily for 7 consecutive days. Group B received the treatments in the opposite order. The index finger tapping test, grip strength test, TST and conventional TMS examination for each hand were recorded before and one week after the administration of venlafaxine or placebo.

RESULTS:

Compared to the placebo stage, in the venlafaxine stage, the number of index finger taps was significantly increased for both hands, and the TST amplitude and area ratios were significantly increased. The improvement in the TST amplitude ratio was significantly and positively correlated with the improvements in performance on the index finger tapping test.

CONCLUSION:

Venlafaxine positively regulates central motor conduction in healthy adults.

KEYWORDS:

Corticospinal tract; Transcranial magnetic stimulation (TMS); Triple stimulation technique (TST); Venlafaxine; motor function; motor-evoked potential

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