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J Biomed Mater Res A. 2018 Jun;106(6):1626-1633. doi: 10.1002/jbm.a.36370. Epub 2018 Mar 3.

Chitosan porous 3D scaffolds embedded with resolvin D1 to improve in vivo bone healing.

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i3S - Instituto de Inovação e Investigação em Saúde, Universidade do Porto, Porto 4200-125, Portugal.
INEB - Instituto de Engenharia Biomédica, Porto 4200-125, Portugal.
ICBAS - Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, Porto 4050-313, Portugal.
UMIB - Unit for Multidisciplinary Biomedical Research of ICBAS - Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto 4050-313, Portugal.
FMUP - Faculdade de Medicina, Universidade do Porto, Porto 4200, Portugal.
Spine Group, Orthopedic Department, Hospital de São João, Porto 4200-319, Portugal.


The aim of this study was to investigate the effect chitosan (Ch) porous 3D scaffolds embedded with resolvin D1 (RvD1), an endogenous pro-resolving lipid mediator, on bone tissue healing. These scaffolds previous developed by us have demonstrated to have immunomodulatory properties namely in the modulation of the macrophage inflammatory phenotypic profile in an in vivo model of inflammation. Herein, results obtained in an in vivo rat femoral defect model demonstrated that two months after Ch + RvD1 scaffolds implantation, an increase in new bone formation, in bone trabecular thickness, and in collagen type I and Coll I/Coll III ratio were observed. These results suggest that Ch scaffolds embedded with RvD1 were able to lead to the formation of new bone with improvement of trabecular thickness. This study shows that the presence of RvD1 in the acute phase of the inflammatory response to the implanted biomaterial had a positive role in the subsequent bone tissue repair, thus demonstrating the importance of innovative approaches for the control of immune responses to biomedical implants in the design of advanced strategies for regenerative medicine.


biomaterials; bone healing; chitosan; immunomodulation; resolvin D1

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