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Adv Exp Med Biol. 2018;1048:143-161. doi: 10.1007/978-3-319-72041-8_9.

Toxicogenomics: A New Paradigm for Nanotoxicity Evaluation.

Author information

1
Department of Applied Physics, Faculty of Engineering and Technology, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
2
Zoology Department, College of Sciences, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
3
Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India.
4
Department of Botany and Microbiology, College of Sciences, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
5
Department of Agricultural Microbiology, Faculty of Agricultural Sciences, Aligarh Muslim University, Aligarh, Uttar Pradesh, India. musarratj1@yahoo.com.
6
Department of Biosciences and Biotechnology, Baba Ghulam Shah Badshah University, Rajouri, Jammu and Kashmir, India. musarratj1@yahoo.com.

Abstract

The wider applications of nanoparticles (NPs) has evoked a world-wide concern due to their possible risk of toxicity in humans and other organisms. Aggregation and accumulation of NPs into cell leads to their interaction with biological macromolecules including proteins, nucleic acids and cellular organelles, which eventually induce toxicological effects. Application of toxicogenomics to investigate molecular pathway-based toxicological consequences has opened new vistas in nanotoxicology research. Indeed, genomic approaches appeared as a new paradigm in terms of providing information at molecular levels and have been proven to be as a powerful tool for identification and quantification of global shifts in gene expression. Toxicological responses of NPs have been discussed in this chapter with the aim to provide a clear understanding of the molecular mechanism of NPs induced toxicity both in in vivo and in vitro test models.

KEYWORDS:

Microarray; Nanoparticles; Oxidative stress; RNA-Seq; Toxicogenomics

PMID:
29453537
DOI:
10.1007/978-3-319-72041-8_9
[Indexed for MEDLINE]

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