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Mol Cell. 2018 Feb 15;69(4):537-538. doi: 10.1016/j.molcel.2018.01.036.

m6A and eIF2α-ⓟ Team Up to Tackle ATF4 Translation during Stress.

Author information

1
Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA 94720, USA.
2
Department of Molecular and Cell Biology, UC Berkeley, Berkeley, CA 94720, USA. Electronic address: gabrar@berkeley.edu.

Abstract

While m6A modification of mRNAs is now known to be widespread, the cellular roles of this modification remain largely mysterious. In this issue of Molecular Cell, Zhou et al. (2018) show that m6A modification unexpectedly contributes to the established uORF- and eIF2α-ⓟ-dependent mechanism of ATF4 translational regulation in response to stress.

PMID:
29452634
DOI:
10.1016/j.molcel.2018.01.036
[Indexed for MEDLINE]
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