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World Neurosurg. 2018 Jun;114:e42-e50. doi: 10.1016/j.wneu.2018.02.017. Epub 2018 Feb 13.

Bone Metabolic Markers in the Clinical Assessment of Patients with Superior Semicircular Canal Dehiscence.

Author information

1
Department of Neurosurgery, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA.
2
Department of Head and Neck Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA.
3
Department of Neurosurgery, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA; Department of Head and Neck Surgery, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA; Department of Radiation Oncology, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA; Jonsson Comprehensive Cancer Center, Ronald Reagan UCLA Medical Center, Los Angeles, California, USA; David Geffen School of Medicine of the University of California, Los Angeles, Los Angeles, California, USA; Department of Neurosurgery, Harbor-UCLA Medical Center, Torrance, California, USA; Los Angeles Biomedical Research Institute (LA BioMed), Harbor-UCLA Medical Center, Torrance, California, USA. Electronic address: iyang@mednet.ucla.edu.

Abstract

BACKGROUND:

Superior semicircular canal dehiscence (SSCD) is a bony defect in the osseous shell of the petrous temporal bone. The pathophysiological association between osteoporosis and SSCD remains poorly understood. We investigated the relationship between bone metabolic markers and symptoms in patients with SSCD.

METHODS:

We collected patient demographics and clinical parameters for adult patients diagnosed with SSCD on high-resolution computed tomography scans. We used point-biserial correlation analysis to investigate the relationship between bone metabolic markers and symptoms in patients with SSCD. We compared clinical symptoms before and after surgical repair of SSCD through a middle fossa craniotomy using McNemar's test for paired comparisons of binary measures.

RESULTS:

We included a total of 99 patients (64 females and 35 males; average age 52 years; 118 surgeries). The level of serum calcium correlated with the need for a second surgery (rpb = -0.35, P = 0.001). Postoperative calcium supplementation negatively correlated with improvement in dizziness (rpb = -0.36, P = 0.01). The level of 25-hydroxyvitamin D correlated with preoperative hyperacusis (rpb = -0.98, P = 0.02) and postoperative autophony (rpb = 0.96, P = 0.04). Postoperative vitamin D supplementation positively correlated with hearing decline (rpb = 0.04, P = 0.04) The level of thyroid stimulating hormone correlated with preoperative autophony, amplification, and tinnitus (rpb = -0.71, rpb = -0.75, rpb = -0.70, all P < 0.001).

CONCLUSIONS:

Bone metabolic markers could be important in the clinical assessment of SSCD patients and could be potential targets for symptom management.

KEYWORDS:

Bone markers; Middle fossa craniotomy; Superior semicircular canal dehiscence

PMID:
29452318
DOI:
10.1016/j.wneu.2018.02.017
[Indexed for MEDLINE]

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