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J Clin Hypertens (Greenwich). 2018 Apr;20(4):775-783. doi: 10.1111/jch.13239. Epub 2018 Feb 16.

Relation of uric acid level to rapid kidney function decline and development of kidney disease: The Jackson Heart Study.

Author information

1
Jackson Heart Study, Jackson State University, Jackson, MS, USA.
2
Department of Medicine, Division of Nephrology, Medical University of South Carolina, Charleston, SC, USA.
3
Medical Services, Ralph H. Johnson VA Medical Center, Charleston, SC, USA.
4
Division of Nephrology, Kidney Research Institute, University of Washington, Seattle, WA, USA.
5
Jackson Heart Study, University of Mississippi Medical Center, Jackson, MS, USA.
6
National Institute of Diabetes, Digestive, and Kidney Diseases, Bethesda, MD, USA.
7
Veterans Affairs Puget Sound Health Care Center, Seattle, WA, USA.

Abstract

Whether elevated uric acid (UA) is an independent risk factor for chronic kidney disease (CKD) is not well established. The authors evaluated the relationship of UA with rapid kidney function decline (RKFD) and incident CKD among 3702 African Americans (AAs) in the Jackson Heart Study with serum UA levels measured at baseline exam (2000-2004). RKFD was defined as ≥ 30% eGFR loss and incident CKD as development of eGFR < 60 mL/min/1.73 m2 with a ≥ 25% decline in eGFR between baseline and exam 3 (2009-2013). RKFD and CKD were found in 11.4% and 7.5% of the participants, respectively. In a fully adjusted model, the odds of RKFD (OR, 1.8; 95% CI, 1.25-2.49) and incident CKD (OR, 2.00; 95% CI, 1.31-3.06) were significantly higher among participants in the top UA quartile vs bottom quartile. In the JHS, elevated UA was significantly associated with RKFD and incident CKD.

KEYWORDS:

African American; CKD progression; albuminuria; chronic kidney disease; estimated glomerular filtration rate; rapid kidney function decline; uric acid

PMID:
29450959
PMCID:
PMC6022371
[Available on 2019-04-01]
DOI:
10.1111/jch.13239
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