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MRS Commun. 2017 Sep;7(3):466-471. doi: 10.1557/mrc.2017.54. Epub 2017 Jul 20.

Decorin-containing collagen hydrogels as dimensionally stable scaffolds to study the effects of compressive mechanical loading on angiogenesis.

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Georgia Institute of Technology, Petit Institute for Bioengineering and Biosciences, Atlanta, GA.
Emory University, Atlanta, GA.
University of Utah, Salt Lake City, UT.
Atlanta Veteran's Affairs Medical Center, Decatur, GA.


Angiogenesis is a critical component during wound healing, and the process is sensitive to mechanical stimuli. Current in vitro culture environments used to investigate three-dimensional microvascular growth often lack dimensional stability and the ability to withstand compression. We investigated the ability of decorin, a proteoglycan known to modulate collagen fibrillogenesis, incorporated into a collagen hydrogel to increase construct dimensional stability while maintaining vascular growth. Decorin did not affect microvascular growth parameters, while increasing the compressive modulus of collagen gels and significantly reducing the contraction of 3% collagen gels after 16 days in culture.

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