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Trends Mol Med. 2018 Mar;24(3):257-277. doi: 10.1016/j.molmed.2018.01.001. Epub 2018 Feb 12.

Therapeutic Targeting of Long Non-Coding RNAs in Cancer.

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Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA; These authors contributed equally.
Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Electronic address:


Long non-coding RNAs (lncRNAs) represent a significant population of the human transcriptome. Many lncRNAs exhibit cell- and/or tissue/tumor-specific expression, making them excellent candidates for therapeutic applications. In this review we discuss examples of lncRNAs that demonstrate the diversity of their function in various cancer types. We also discuss recent advances in nucleic acid drug development with a focus on oligonucleotide-based therapies as a novel approach to inhibit tumor progression. The increased success rates of nucleic acid therapeutics provide an outstanding opportunity to explore lncRNAs as viable therapeutic targets to combat various aspects of cancer progression.

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