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Diagn Microbiol Infect Dis. 2018 Jun;91(2):144-146. doi: 10.1016/j.diagmicrobio.2018.01.012. Epub 2018 Feb 2.

The Verigene dilemma: gram-negative polymicrobial bloodstream infections and clinical decision making.

Author information

1
Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, Maryland, USA. Electronic address: kclaeys@rx.umaryland.edu.
2
Pharmacy Practice and Science, University of Maryland School of Pharmacy, Baltimore, Maryland, USA.
3
Pharmacy Practice, Detroit Medical Center, Detroit, Michigan, USA.
4
Microbiology, Detroit Medical Center, Detroit, Michigan, USA.
5
Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.

Abstract

Verigene Blood-Culture Gram-Negative (GN) results in rapid identification of key GNs in bloodstream infections. Its use clinically is limited by low sensitivity in polymicrobial GN infections and concerns for inappropriate antibiotic modification. In a retrospective review of 1003 blood culture sets, the incidence of missed GNs was infrequent, <4%, with the potential to negatively impact the management of GN BSIs in <2% of cases.

KEYWORDS:

Bloodstream infection; Gram-negative; Microarray; Polymicrobial; Rapid diagnostics

[Indexed for MEDLINE]

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