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Med Hypotheses. 2018 Mar;112:4-6. doi: 10.1016/j.mehy.2018.01.005. Epub 2018 Jan 30.

Biofilms busters to improve the detection of Borrelia using PCR.

Author information

1
Centre de diagnostic, ELSAN, Centre médico - chirurgical, 83 avenue Charles de Gaulle, 15000 Aurillac, France. Electronic address: lacout.alexis@wanadoo.fr.
2
Centre de diagnostic, 29 ter Avenue Jean Jaurès, 63200 Mozac, France. Electronic address: veroniquedacher7@orange.fr.
3
Service de diagnostic, Hôpital Ambroise PARE (APHP), 9, Avenue Charles de GAULLE, 92100 Boulogne Billancourt, France. Electronic address: elhajjam.mostafa@wanadoo.fr.
4
Radiodiagnostics and Interventional Radiology Department, Polyclinique Les Fleurs, Quartier Quiez, 83190 Ollioules, France. Electronic address: brozpy@gmail.com.
5
Infectious Diseases Unit, University Hospital Raymond Poincaré, APHP, Versailles Saint Quentin University, Garches, France. Electronic address: c.perronne@aphp.fr.

Abstract

Lyme disease is an affection caused by a spirochete infection called Borrelia Burgdorferi which may harbor a varied and misleading clinical symptomatology. The serology tests commonly used for diagnosis show a wide sensitivity varying from 34% to 70,5%, leaving many infected patients with false negative tests. Alternative techniques such as polymerase chain reaction (PCR) could be helpful but not conclusive enough. Using biofilm busters, such as stevia and serratiopeptidase, could lead to bacterial blood release, thus increasing the spirochete load, making PCR test more sensitive, thus improving the patient's diagnosis and management.

KEYWORDS:

Biofilms; Borrelia; Lyme; PCR; Serratiopeptidase; Stevia

PMID:
29447935
DOI:
10.1016/j.mehy.2018.01.005
[Indexed for MEDLINE]

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