Send to

Choose Destination
Head Neck Pathol. 2018 Dec;12(4):623-628. doi: 10.1007/s12105-018-0895-5. Epub 2018 Feb 14.

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report Documenting the Potential for Very Late Tumor Recurrence.

Author information

Department of Pathology, Cleveland Clinic Foundation, Robert J. Tomsich Pathology and Laboratory Medicine Institute, 9500 Euclid Avenue/L25, Cleveland, OH, 44195, USA.
Head and Neck Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. CS3.620, Dallas, TX, 75390, USA.


Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a peculiar sinonasal tract tumor that demonstrates features of both a surface-derived and salivary gland carcinoma. Implicit in its name, this tumor has a consistent association with high-risk HPV, particularly type 33. It was first described in 2013 under the designation of HPV-related carcinoma with adenoid cystic carcinoma-like features. However, since its initial description additional cases have emerged which demonstrate a wide morphologic spectrum and relatively indolent clinical behavior. Herein we report our experience with a case of HPV-related multiphenotypic sinonasal carcinoma that was initially classified as adenoid cystic carcinoma in the 1980s. The patient recurred after a 30-year disease free interval. RNA in situ hybridization confirmed the presence of high-risk HPV in both her recurrence and her initial tumor in the 1980s, which allowed for reclassification as HPV-related multiphenotypic sinonasal carcinoma. Our case adds to the literature of this relatively newly described entity and supports the indolent clinical behavior of this neoplasm but also demonstrates a potential for very late local recurrence.


Adenoid cystic carcinoma; Carcinoma with adenoid cystic-like features; Human papillomavirus; Multiphenotypic sinonasal carcinoma; Sinonasal carcinoma

[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Springer Icon for PubMed Central
Loading ...
Support Center