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Head Neck Pathol. 2018 Dec;12(4):623-628. doi: 10.1007/s12105-018-0895-5. Epub 2018 Feb 14.

Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma: A Case Report Documenting the Potential for Very Late Tumor Recurrence.

Author information

1
Department of Pathology, Cleveland Clinic Foundation, Robert J. Tomsich Pathology and Laboratory Medicine Institute, 9500 Euclid Avenue/L25, Cleveland, OH, 44195, USA. shaha8@ccf.org.
2
Head and Neck Institute, Cleveland Clinic Foundation, 9500 Euclid Ave, Cleveland, OH, 44195, USA.
3
Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd. CS3.620, Dallas, TX, 75390, USA.

Abstract

Human papillomavirus (HPV)-related multiphenotypic sinonasal carcinoma is a peculiar sinonasal tract tumor that demonstrates features of both a surface-derived and salivary gland carcinoma. Implicit in its name, this tumor has a consistent association with high-risk HPV, particularly type 33. It was first described in 2013 under the designation of HPV-related carcinoma with adenoid cystic carcinoma-like features. However, since its initial description additional cases have emerged which demonstrate a wide morphologic spectrum and relatively indolent clinical behavior. Herein we report our experience with a case of HPV-related multiphenotypic sinonasal carcinoma that was initially classified as adenoid cystic carcinoma in the 1980s. The patient recurred after a 30-year disease free interval. RNA in situ hybridization confirmed the presence of high-risk HPV in both her recurrence and her initial tumor in the 1980s, which allowed for reclassification as HPV-related multiphenotypic sinonasal carcinoma. Our case adds to the literature of this relatively newly described entity and supports the indolent clinical behavior of this neoplasm but also demonstrates a potential for very late local recurrence.

KEYWORDS:

Adenoid cystic carcinoma; Carcinoma with adenoid cystic-like features; Human papillomavirus; Multiphenotypic sinonasal carcinoma; Sinonasal carcinoma

PMID:
29445997
PMCID:
PMC6232222
DOI:
10.1007/s12105-018-0895-5
[Indexed for MEDLINE]
Free PMC Article

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