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J Biol Res (Thessalon). 2018 Feb 5;25:3. doi: 10.1186/s40709-018-0075-5. eCollection 2018 Dec.

Bone marrow stem cells to destroy circulating HIV: a hypothetical therapeutic strategy.

Author information

1
Department of Zoology, Raniganj Girls' College, Searsole, Rajbari, Raniganj, Paschim Barddhaman, West Bengal 713358 India.

Abstract

Human immunodeficiency virus (HIV) still poses enigmatic threats to human life. This virus has mastered in bypassing anti retroviral therapy leading to patients' death. Circulating viruses are phenomenal for the disease outcome. This hypothesis proposes a therapeutic strategy utilizing receptor-integrated hematopoietic, erythroid and red blood cells. Here, HIV specific receptors trap circulating viruses that enter erythrocyte cytoplasm and form inactive integration complex. This model depicts easy, effective removal of circulating HIV without any adverse effect.

KEYWORDS:

AIDS; Burst-forming unit-erythrocyte; HIV; HIV receptors; HIV therapy; Hematopoietic stem cell; Red blood cell

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