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Clin Case Rep. 2017 Dec 20;6(2):258-261. doi: 10.1002/ccr3.1288. eCollection 2018 Feb.

Stevens-Johnson syndrome/toxic epidermal necrolysis associated with zonisamide.

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Department of Dermatology and Cutaneous Surgery University of South Florida Tampa Florida.


This report highlights zonisamide as a potential cause of serious cutaneous reactions as well as its cross-reactivity with other sulfonamides. Here, we present a case of SJS-TEN due to zonisamide, which was effectively treated with IVIg. Subsequently, the patient was transitioned to levetiracetam for seizure control.


Drug rash; Stevens–Johnson syndrome; pediatric; toxic epidermal necrolysis; zonisamide

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