Format

Send to

Choose Destination
Cell Rep. 2018 Feb 13;22(7):1787-1797. doi: 10.1016/j.celrep.2018.01.016.

Mechanisms to Evade the Phagocyte Respiratory Burst Arose by Convergent Evolution in Typhoidal Salmonella Serovars.

Author information

1
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA.
2
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address: twangdi@wustl.edu.
3
Department of Pediatrics, School of Medicine, University of California San Diego, La Jolla, CA 92093, USA.
4
Department of Pathology, School of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
5
Department of Medical Microbiology and Immunology, School of Medicine, University of California, Davis, Davis, CA 95616, USA. Electronic address: ajbaumler@ucdavis.edu.

Abstract

Typhoid fever caused by Salmonella enterica serovar (S.) Typhi differs in its clinical presentation from gastroenteritis caused by S. Typhimurium and other non-typhoidal Salmonella serovars. The different clinical presentations are attributed in part to the virulence-associated capsular polysaccharide (Vi antigen) of S. Typhi, which prevents phagocytes from triggering a respiratory burst by preventing antibody-mediated complement activation. Paradoxically, the Vi antigen is absent from S. Paratyphi A, which causes a disease that is indistinguishable from typhoid fever. Here, we show that evasion of the phagocyte respiratory burst by S. Paratyphi A required very long O antigen chains containing the O2 antigen to inhibit antibody binding. We conclude that the ability to avoid the phagocyte respiratory burst is a property distinguishing typhoidal from non-typhoidal Salmonella serovars that was acquired by S. Typhi and S. Paratyphi A independently through convergent evolution.

KEYWORDS:

capsular polysaccharide; complement; lipopolysaccharide; natural IgM; neutrophil; paratyphoid fever; respiratory burst; typhoid fever

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center