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Viruses. 2018 Feb 14;10(2). pii: E85. doi: 10.3390/v10020085.

The Microbial Zoo in the C. elegans Intestine: Bacteria, Fungi and Viruses.

Author information

1
Departments of Molecular Microbiology and Pathology & Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA. hongbingjiang@wustl.edu.
2
Departments of Molecular Microbiology and Pathology & Immunology, Washington University in St. Louis School of Medicine, St. Louis, MO 63110, USA. davewang@wustl.edu.

Abstract

C. elegans is an invaluable model organism that has been a driving force in many fundamental biological discoveries. However, it is only in the past two decades that it has been applied to host-pathogen interaction studies. These studies have been facilitated by the discoveries of natural microbes that infect C. elegans, including bacteria, fungi and viruses. Notably, many of these microbes share a common site of infection, the C. elegans intestine. Furthermore, the recent descriptions of a natural gut microbiota in C. elegans raise the possibility that this could be a novel model system for microbiome and trans-kingdom interaction studies. Here we review studies of C. elegans host-microbe interactions with a particular focus on the intestine.

KEYWORDS:

C. elegans; bacteria; fungi; host–pathogen interaction; intestine; microbiome; trans-kingdom interactions; viruses

PMID:
29443938
PMCID:
PMC5850392
DOI:
10.3390/v10020085
[Indexed for MEDLINE]
Free PMC Article

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