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JPEN J Parenter Enteral Nutr. 2018 Feb;42(2):279-295. doi: 10.1002/jpen.1121.

Proceedings of the 2017 ASPEN Research Workshop-Gastric Bypass: Role of the Gut.

Author information

1
Department of Pediatrics, SSM Cardinal Glennon Children's Medical Center, Saint Louis University School of Medicine, Saint Louis, Missouri, USA.
2
Diabetes Complications Research Center, University College Dublin, School of Medicine, Dublin, Ireland.
3
Division of Gastroenterology, Hepatology and Nutrition, Virginia Commonwealth University, Richmond, Vieginia, USA.
4
Brigham and Women's Hospital, Center for Weight Management and Metabolic Surgery, Harvard Medical School, Boston, Massachusetts, USA.
5
Nutrition Science, Purdue University, West Lafayette, Indiana, USA.
6
Department of Medicine, Division of Endocrinology, Columbia University, New York, New York, USA.
7
Baylor College of Medicine, Texas Children's Hospital, Houston, Texas, USA.
8
Division of Gastroenterology and Hepatology, Mayo Clinic, Phoenix, Arizona, USA.
9
Oregon Health and Science University, Portland, Oregon, USA.

Abstract

The goal of the National Institutes of Health-funded American Society for Parenteral and Enteral Nutrition 2017 research workshop (RW) "Gastric Bypass: Role of the Gut" was to focus on the exciting research evaluating gut-derived signals in modulating outcomes after bariatric surgery. Although gastric bypass surgery has undoubted positive effects, the mechanistic basis of improved outcomes cannot be solely explained by caloric restriction. Emerging data suggest that bile acid metabolic pathways, luminal contents, energy balance, gut mucosal integrity, as well as the gut microbiota are significantly modulated after bariatric surgery and may be responsible for the variable outcomes, each of which was rigorously evaluated. The RW served as a timely and novel academic meeting that brought together clinicians and researchers across the scientific spectrum, fostering a unique venue for interdisciplinary collaboration among investigators. It promoted engaging discussion and evolution of new research hypotheses and ideas, driving the development of novel ameliorative, therapeutic, and nonsurgical interventions targeting obesity and its comorbidities. Importantly, a critical evaluation of the current knowledge regarding gut-modulated signaling after bariatric surgery, potential pitfalls, and lacunae were thoroughly addressed.

KEYWORDS:

bariatric surgery; diabetes; endocrinology; liver disease; metabolic syndrome; microbiome; obesity

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