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Ann Pharmacother. 2018 Jul;52(7):645-649. doi: 10.1177/1060028018759637. Epub 2018 Feb 14.

Pyridoxine Add-On Treatment for the Control of Behavioral Adverse Effects Induced by Levetiracetam in Children: A Case-Control Prospective Study.

Author information

1
1 University Hospital Policlinico-Vittorio Emanuele, Catania, Italy.
2
2 Catania University, Italy.

Abstract

BACKGROUND:

Few studies on adult and pediatric patients have shown pyridoxine efficacy as additional therapy for those receiving levetiracetam (LEV) to prevent and mitigate behavioral adverse effects (BAEs).

OBJECTIVE:

The aim of our study was to analyze the safety and efficacy of pyridoxine supplementation in the prevention of LEV adverse effects, including suicidal ideation.

METHODS:

This randomized, case-control trial included patients receiving LEV as monotherapy treatment. Patients were subdivided into 2 groups, according to whether they were treated with LEV only (group 1) or LEV with supplemental pyridoxine (group 2).

RESULTS:

In both cohorts, the most frequent BAEs were irritability/aggression followed by depression and confusion. Those patients (92%) who initiated pyridoxine after 1 month of LEV treatment did not need to change or suspend LEV ( P < 0.001), and BAE improved after 9.06 ± 3.05 days of pyridoxine supplementation. None of the patients complained of symptoms of pyridoxine toxicity, and no new adverse effects of LEV off-label were reported.

CONCLUSIONS:

In our study, we found pyridoxine to be safe and effective in controlling LEV-induced BAEs in children.

KEYWORDS:

behavioral adverse effects; child; levetiracetam; pyridoxine

PMID:
29442544
DOI:
10.1177/1060028018759637
[Indexed for MEDLINE]

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