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Minerva Endocrinol. 2018 Dec;43(4):398-405. doi: 10.23736/S0391-1977.18.02725-6. Epub 2018 Feb 13.

Association of heterogeneity of the thyroid gland with matrix metalloproteinase-3 in rheumatoid arthritis patients with Hashimoto's thyroiditis.

Author information

1
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University, Graduate School of Medicine, Osaka, Japan - toshi-n@jg7.so-net.ne.jp.
2
Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University, Graduate School of Medicine, Osaka, Japan.
3
Department of Surgical Oncology, Osaka City University, Graduate School of Medicine, Osaka, Japan.

Abstract

BACKGROUND:

Hashimoto's thyroiditis (HT) is highly prevalent in patients with rheumatoid arthritis (RA). The aim is to determine their relation, focusing on matrix metalloproteinase-3 (MMP-3), a marker predicting joint destruction and RA activity.

METHODS:

Fifty-three consecutive RA patients were prospectively separated into two groups based on the presence or absence of HT; those with and without TPO-Ab or Tg-Ab (34.0% and 66.0%, respectively). To estimate the extent of inflammation and destruction of the thyroid gland, Heterogeneity Index (HI) was determined ultrasonographically.

RESULTS:

While the male/female ratio, TSH and HI were significantly higher in those with HT than in those without (5/13 vs. 7/28, P=0.047, mean±SE; 7.25±0.69 vs.2.52±0.30 mIU/L, P<0.001; 3.8±0.2 vs.3.2±0.2%, P=0.042, respectively), no differences existed in MMP-3. In those with HT, MMP-3 correlated negatively with FT3 (rho=-0.545, P=0.048) and positively with TPO-Ab and HI (rho=0.735, P=0.02; rho=0.769, P=0.01, respectively). Among them, HI was a significant factor associated positively with MMP-3 (r=0.883, F=31.91).

CONCLUSIONS:

The present study demonstrated significant increases of HI and an association between HI and MMP-3 in RA patients with HT. These findings suggest that the inflammation and destruction of the thyroid gland might be closely related to the current activity and terminal joint destruction of RA.

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