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Sci Rep. 2018 Feb 13;8(1):2889. doi: 10.1038/s41598-018-21178-3.

Hydrophilic fluorinated molecules for spectral 19F MRI.

Author information

1
Department of Pediatric Radiology, Texas Children's Hospital, Houston, TX, 77030, USA. eatanifu@texaschildrens.org.
2
Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA. eatanifu@texaschildrens.org.
3
Department of Pediatric Radiology, Texas Children's Hospital, Houston, TX, 77030, USA.
4
Department of Biomedical Engineering, UT Southwestern Medical Center, Dallas, TX, USA.
5
School of Medicine, Baylor College of Medicine, Houston, TX, 77030, USA.
6
Department of Radiology, Baylor College of Medicine, Houston, TX, 77030, USA.
7
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, TX, 77030, USA.

Abstract

Fluorine-19 (19F) Magnetic Resonance Imaging (MRI) is an emerging modality for molecular imaging and cell tracking. The hydrophobicity of current exogenous probes, perfluorocarbons (PFCs) and perfluoropolyethers (PFPEs), limits the formulation options available for in vivo applications. Hydrophilic probes permit more formulation flexibility. Further, the broad Nuclear Magnetic Resonance (NMR) chemical shift range of organofluorine species enables multiple probes with unique 19F MR signatures for simultaneous interrogation of distinct molecular targets in vivo. We report herein a flexible approach to stable liposomal formulations of hydrophilic fluorinated molecules (each bearing numerous magnetically equivalent 19F atoms), with 19F encapsulation of up to 22.7 mg/mL and a per particle load of 3.6 × 106 19F atoms. Using a combination of such probes, we demonstrate, with no chemical shift artifacts, the simultaneous imaging of multiple targets within a given target volume by spectral 19F MRI.

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