Format

Send to

Choose Destination
Biosci Rep. 2018 Feb 12. pii: BSR20171438. doi: 10.1042/BSR20171438. [Epub ahead of print]

Caspase-1 regulate AngII-induced cardiomyocyte hypertrophy via upregulation of IL-1β.

Author information

1
Pharmacology, Harbin Medical University, Harbin, China baiyunlong@ems.hrbmu.edu.cn.
2
Pharmacology, Harbin Medical University, Harbin, China.
3
Chronic Disease Research Institute, Harbin Medical University, Harbin, China.
4
Translational Medicine Research and Cooperation Center of Northern China, Harbin, China.

Abstract

Cardiac hypertrophy is a compensatory response to stress or stimuli, which results in arrhythmia and heart failure. Although multiple molecular mechanisms have been identified, cardiac hypertrophy is still difficult to treat. Pyroptosis is a caspase-1 dependent pro-inflammatory programmed cell death. Caspase-1 is involved in various types of diseases, including hepatic injury, cancers, and diabetes related complications. However, the exact role of caspase-1 in cardiac hypertrophy is yet to be discovered. The present study aimed to explore the possible role of caspase-1 in pathogenesis of cardiac hypertrophy. We established cardiac hypertrophy models both in vivo and in vitro to detect the expression of caspase-1 and IL-1β. The results showed that caspase-1 and IL-1β expression levels were significantly upregulated during cardiac hypertrophy. Subsequently, caspase-1 inhibitor was co-administered with angiotensin II (Ang II) in cardiomyocytes to observe whether it could attenuate cardiac hypertrophy. Results showed that caspase-1 attenuated the pro-hypertrophic effect of Ang II, which was related to the downregulation of caspase-1 and IL-1β. In conclusion, our results provide a novel evidence that caspase-1 mediated pyroptosis is involved in cardiac hypertrophy, and the inhibition of caspase-1 will offer a therapeutic potential against cardiac hypertrophy.

KEYWORDS:

Cardiac hypertrophy; IL-1β; caspase-1; pyroptosis

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center