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J Exp Med. 2018 Mar 5;215(3):723-724. doi: 10.1084/jem.20180241. Epub 2018 Feb 12.

Defusing inflammasomes.

Author information

1
Howard Hughes Medical Institute and Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA sandstrom@berkeley.edu.
2
Howard Hughes Medical Institute and Division of Immunology and Pathogenesis, Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, CA rvance@berkeley.edu.

Abstract

In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.

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