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Cancer Res. 2018 May 1;78(9):2356-2369. doi: 10.1158/0008-5472.CAN-17-2511. Epub 2018 Feb 12.

FOXO Transcription Factors Both Suppress and Support Breast Cancer Progression.

Author information

1
Oncode Institute, University Medical Center Utrecht, Utrecht University, the Netherlands.
2
Center for Molecular Medicine, Molecular Cancer Research, University Medical Center Utrecht, Utrecht University, the Netherlands.
3
Department of Pathology, University Medical Center Utrecht, Utrecht University, the Netherlands.
4
Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands.
5
Oncode Institute, University Medical Center Utrecht, Utrecht University, the Netherlands. t.b.dansen@umcutrecht.nl b.m.t.burgering@umcutrecht.nl.
6
Center for Molecular Medicine, Molecular Cancer Research, University Medical Center Utrecht, Utrecht University, the Netherlands. t.b.dansen@umcutrecht.nl b.m.t.burgering@umcutrecht.nl.
#
Contributed equally

Abstract

FOXO transcription factors are regulators of cellular homeostasis and putative tumor suppressors, yet the role of FOXO in cancer progression remains to be determined. The data on FOXO function, particularly for epithelial cancers, are fragmentary and come from studies that focused on isolated aspects of cancer. To clarify the role of FOXO in epithelial cancer progression, we characterized the effects of inducible FOXO activation and loss in a mouse model of metastatic invasive lobular carcinoma. Strikingly, either activation or loss of FOXO function suppressed tumor growth and metastasis. We show that the multitude of cellular processes critically affected by FOXO function include proliferation, survival, redox homeostasis, and PI3K signaling, all of which must be carefully balanced for tumor cells to thrive.Significance: FOXO proteins are not solely tumor suppressors, but also support tumor growth and metastasis by regulating a multitude of cellular processes essential for tumorigenesis. Cancer Res; 78(9); 2356-69. ©2018 AACR.

PMID:
29440168
DOI:
10.1158/0008-5472.CAN-17-2511
[Indexed for MEDLINE]
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