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Int J Mol Sci. 2018 Feb 12;19(2). pii: E551. doi: 10.3390/ijms19020551.

The Neuroprotective Effects of Cinnamic Aldehyde in an MPTP Mouse Model of Parkinson's Disease.

Author information

1
Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea. woom8875@khu.ac.kr.
2
Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea. ChoiJS@khu.ac.kr.
3
Department of Biomedical Science, Graduate School, Kyung Hee University, Seoul 02447, Korea. jjeong@khu.ac.kr.
4
Department of Anatomy and Neurobiology, College of Medicine, Kyung Hee University, Seoul 02447, Korea. jjeong@khu.ac.kr.

Abstract

Cinnamic aldehyde (CA), a key flavor compound in cinnamon essential oil, has been identified as an anti-oxidant, anti-angiogenic, and anti-inflammatory material. Recently, the neuroprotective effects of CA have been reported in various neurodegenerative disorders, including Parkinson's disease (PD). In neurons, autophagy is tightly regulated, and consequently, the dysregulation of autophagy may induce neurodegenerative disorders. In the present study, we found that the selective dopaminergic neuronal death in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) mouse models was prevented by CA. Stimulation of microtubule-associated protein light chain 3 (LC3) puncta mediated by MPTP treatment was decreased by CA. Moreover, down-regulated p62 in the substantia nigra of MPTP mice was increased by administration of CA. Finally, we showed that blockage of autophagy using autophagy inhibitors protected the 1-methyl-4-phenylpyridinium (MPP⁺)-mediated death of BE(2)-M17 cells. Together these results suggest that CA has a neuroprotective effect in a PD model and that inhibition of autophagy might be a promising therapeutic target for PD.

KEYWORDS:

MPP+; MPTP; Parkinson’s disease; autophagy; cinnamic aldehyde

PMID:
29439518
PMCID:
PMC5855773
DOI:
10.3390/ijms19020551
[Indexed for MEDLINE]
Free PMC Article

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