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Sci Data. 2018 Feb 13;5:180010. doi: 10.1038/sdata.2018.10.

Dataset of human medial temporal lobe single neuron activity during declarative memory encoding and recognition.

Author information

1
Department of Neurosurgery, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
2
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA 91125, USA.
3
Department of Neurosurgery, Huntington Memorial Hospital, Pasadena, CA 91125, USA.
4
Department of Neurology, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
5
Computation and Neural Systems Program, California Institute of Technology, Pasadena, CA 91125, USA.
6
Center for Neural Science and Medicine, Department of Biomedical Science, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.

Abstract

We present a dataset of 1,576 single neurons recorded from the human amygdala and hippocampus in 65 sessions from 42 patients undergoing intracranial monitoring for localization of epileptic seizures. Subjects performed a recognition memory task with pictures as stimuli. Subjects were asked to identify whether they had seen a particular image the first time ('new') or second time ('old') on a 1-6 confidence scale. This comprehensive dataset includes the spike times of all neurons and their extracellular waveforms, behavior, electrode locations determined from post-operative MRI scans, demographics, and the stimuli shown. As technical validation, we provide spike sorting quality metrics and assessment of tuning of cells to verify the presence of visually-and memory selective cells. We also provide analysis code that reproduces key scientific findings published previously on a smaller version of this dataset. Together, this large dataset will facilitate the investigation of the neural mechanism of declarative memory by providing a substantial number of hard to obtain human single-neuron recordings during a well characterized behavioral task.

PMID:
29437158
PMCID:
PMC5810422
DOI:
10.1038/sdata.2018.10
[Indexed for MEDLINE]
Free PMC Article

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