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Endocr Metab Immune Disord Drug Targets. 2018;18(4):333-340. doi: 10.2174/1871530318666180213113211.

Benefits of Olive Oil Phenolic Compounds in Disease Prevention.

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Department of Nursing, Faculty of Health Sciences, University of Granada, Avda. Ilustracion, 60, 18016, Granada, Spain.
Instituto Investigacion Biosanitaria, ibs.Granada. C/ Dr. Azpitarte 4 - 4ª planta. 18012 Granada, Spain.
Institute of Neuroscience Federico Olóriz, University of Granada, Avda. del Conocimiento S/N. 18016. Armilla, Granada, Spain.
Department of Nursing, Faculty of Health Sciences (Melilla), University of Granada, Camino Cdad, De Malaga 22, 52005, Melilla, Spain.



The preventive effects of olive oil against different diseases have been attributed to its high phenolic compound content. The objective of this study was to examine available scientific evidence on the beneficial effects against chronic diseases of olive oil phenolic compounds.


This article examines recently published data on olive oil phenolic compounds and their potential benefits in the prevention of cardiovascular disease, cancer, neurodegenerative disease, and osteoporosis.


The antioxidant, anti-proliferative, pro-apoptotic, and anti-inflammatory activities of olive oil phenolic compounds have preventive effects against heart disease and cancer. These compounds also exert neuroprotective and neuromodulator effects against neurodegenerative disease, inhibiting the development of amyloid plaques. Finally, they are known to protect against osteoporosis, favoring bone regeneration.


Dietary intake of olive oil can be recommended by healthcare professionals as an important source of phenolic compounds that play a role in the prevention of chronic disease and the consequent improvement in quality of life.


Olive oil; cancer; cardiovascular disease; neurodegenerative disease; osteoporosis; phenolic compounds.

[Indexed for MEDLINE]

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